It has,and is known,that those who are taking Haloperidol do relapse during its therapy. Many have expressed doubt as to its ability of an anti-psychotic other than the approved tolerability. The argument for conventional agents such as Risperidone increases.
Risperidone and Clozapine are both more effective in treating " negative " schizophrenia symptoms such as withdrawal from social interactions and blunted emotional expression.
For " positive " symptoms of delusions and hallucinations,Risperidone was found to be superior in a combined analysis of large controlled trials.
Risperidone was found to reduce the numbers of relapses which occurred during schizophrenia or schizoaffective disorders compared with Haloperidol, as well as being tolerant.
The full clinical benefits of treatment with antipsychotic drugs should be judged over an extended period.