Sheila's toxicology report:

[lookout]

At death she was found to have in her system, an adequate and theraputic amount of Haloperidol, low to moderate doses of which have been found to be adequate for most severely psychotic patients, which would have been efficacious until her next dose, which I believe to have been due sometime the following week.

Regarding heart meds, my adored M. often had his changed according to what his doctors felt was necessary. The balance is all important. A theraputic dose, not more than, is all that's necessary.

Sheila's final dose wasn't therapeutic Jane, it was dangerously low.
I certainly agree about balance and regularity too.

[Jane]

Sheila's final dose wasn't therapeutic Jane, it was dangerously low.
I certainly agree about balance and regularity too.

No, Lookout, I'm sorry, but I don't believe it was. I'm going by the paper I've already quoted. They don't just carry out tests from observation, alone, they have to take bloods from hundreds of patients, as well as a control group, and tests will be carried out over long periods before outcomes are arrived at. Their finding is that "LOW to MODERATE doses provide adequate and theraputic cover for most severely psychotic patients". Sheila wasn't severely psychotic and she had enough Haloperidol in her system to have kept her, had she lived, adequately medicated until her next dose. Of course, it can always be argued that Sheila MAY have been the one, in however many hundreds of thousands, to whom it doesn't apply, but there seems to be nothing in her history to suggest such.

[guest29835]

At death she was found to have in her system, an adequate and theraputic amount of Haloperidol, low to moderate doses of which have been found to be adequate for most severely psychotic patients, which would have been efficacious until her next dose, which I believe to have been due sometime the following week.

Regarding heart meds, my adored M. often had his changed according to what his doctors felt was necessary. The balance is all important. A theraputic dose, not more than, is all that's necessary.

You are taking the apparent findings of a paper you quoted (and that you have not read) out of context in order to make a different argument. 

Sheila's dosage had been negligently reduced, the concentration of Haloperidol in her body was small by her death, and she was only days from her next dosage.  She was taking cannabis, and probably drinking and taking cocaine.

In my view, the pharmacology/toxicology aspects of this case have not been considered in sufficient depth.

[Steve_uk]

You are taking the apparent findings of a paper you quoted (and that you have not read) out of context in order to make a different argument. 

Sheila's dosage had been negligently reduced, the concentration of Haloperidol in her body was small by her death, and she was only days from her next dosage.  She was taking cannabis, and probably drinking and taking cocaine.

In my view, the pharmacology/toxicology aspects of this case have not been considered in sufficient depth.

There's still no evidence that she was a mortal risk to others.

[guest29835]

There's still no evidence that she was a mortal risk to others.

I agree, but that doesn't matter.  A would-be killer is of no mortal risk to others until he embarks on his killing.

I could add that there's no evidence that Jeremy Bamber was violent in the least, whereas Julie Mugford was violent towards Jeremy Bamber, and Sheila Caffell was violent towards Colin Caffell, and allegedly towards the twins.

[snow66!]

I agree, but that doesn't matter.  A would-be killer is of no mortal risk to others until he embarks on his killing.

I could add that there's no evidence that Jeremy Bamber was violent in the least, whereas Julie Mugford was violent towards Jeremy Bamber, and Sheila Caffell was violent towards Colin Caffell, and allegedly towards the twins.

Good point Gascoigne,if there was any evidence of fist fights or such,no doubt this would have been brought up and argued he had a violent nature.

[Steve_uk]

I agree, but that doesn't matter.  A would-be killer is of no mortal risk to others until he embarks on his killing.

I could add that there's no evidence that Jeremy Bamber was violent in the least, whereas Julie Mugford was violent towards Jeremy Bamber, and Sheila Caffell was violent towards Colin Caffell, and allegedly towards the twins.

There's no evidence that the twins were ever a recipient of violence. This is again scurrilous rumour, which I'm surprised (or am I?) you seem to have swallowed hook, line and sinker. Julie threw a bar of Shield soap into a shopping cart in a Maldon supermarket and it hit Jeremy on the nose, so maybe she should be escorted to Styal prison forthwith. Jeremy pinned Julie's arm behind her back at Moreshead Mansions, when he realized the truth was finally about to emerge.

[Adam]

I agree, but that doesn't matter.  A would-be killer is of no mortal risk to others until he embarks on his killing.

I could add that there's no evidence that Jeremy Bamber was violent in the least, whereas Julie Mugford was violent towards Jeremy Bamber, and Sheila Caffell was violent towards Colin Caffell, and allegedly towards the twins.

Julie was in London on the massacre night.

What did Sheila do to CC?

[Steve_uk]

Julie was in London on the massacre night.

What did Sheila do to CC?

She destroyed some of his artwork and threw a pan at him.

[Jane]

Am surprised you cannot find it Adam 

Thanks for this, Rob. Having read it and reread it, it supports everything I've said

[David1819]

Sheila had 15 ng/mL of haloperidol in her blood at the time of her death.



According to a 1992 study "Haloperidol Blood Levels and Clinical Effects" They consider Haloperidol blood levels as follows -

low (2 to 13 ng/mL), medium (13.1 to 24 ng/mL), or high (24.1 to 35 ng/mL).

According to a 1980s study, heavy sedation is associated with levels in excess of 50ng/mL

[lookout]

Thanks for that David.

[Adam]

Sheila had 15 ng/mL of haloperidol in her blood at the time of her death.



According to a 1992 study "Haloperidol Blood Levels and Clinical Effects" They consider Haloperidol blood levels as follows -

low (2 to 13 ng/mL), medium (13.1 to 24 ng/mL), or high (24.1 to 35 ng/mL).

According to a 1980s study, heavy sedation is associated with levels in excess of 50ng/mL

Another source saying Haloperidal causes sedation.

Sheila was able to visit Bamber on the farm. Then say 'Yes/No' to PB for 3 minutes. So was probably on mild to medium sedation.

[snow66!]

Another source saying Haloperidal causes sedation.

Sheila was able to visit Bamber on the farm. Then say 'Yes/No' to PB for 3 minutes. So was probably on mild to medium sedation.

Enough to give up her life without any struggle Adam?

[lookout]

Sedation only when fully medicated----Sheila wasn't.