Different only when tested. All blood smells the same with metallic overtones on account of the iron content so AE was wrong when she said she could tell the difference either by smell or colour.
If the relatives were going to attempt such an intricate frame, you would think they would check to see if it was the right type of blood.
Getting caught attempting to frame a man of 5x murder would carry a severe punishment.
However it is confirmed the relatives could only attempt this by putting someone else's blood into the silencer. Then hopeing it matches Sheila's.
David's blood in a bucket of water theory is dismissed.